SrasV1, Main, Exploration, bibRecord, 001E77

IFITM3 restricts the morbidity and mortality associated with influenza

Identifieur interne : 001E77 ( Main/Exploration ); précédent : 001E76; suivant : 001E78

IFITM3 restricts the morbidity and mortality associated with influenza

Source :

Nature [ 0028-0836 ] ; 2012-04-26.

RBID : ISTEX:4CA956BB16447D390A0DA4468EA180D265F7F437

Abstract

Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.

Url:

https://api.istex.fr/ark:/67375/GT4-THQVZLXP-K/fulltext.pdf

DOI: 10.1038/nature10921

Affiliations:

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<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA</wicri:regionArea>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA</wicri:regionArea>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA</wicri:regionArea>
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<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
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<wicri:regionArea>Centre for Respiratory Infection, National Heart and Lung Institute, St Mary’s Campus, Imperial College London, W2 1PG</wicri:regionArea>
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<author><name sortKey="Dougan, Gordon" sort="Dougan, Gordon" uniqKey="Dougan G" first="Gordon" last="Dougan">Gordon Dougan</name>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA</wicri:regionArea>
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<author><name sortKey="Brass, Abraham L" sort="Brass, Abraham L" uniqKey="Brass A" first="Abraham L." last="Brass">Abraham L. Brass</name>
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<wicri:regionArea>Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Charlestown, Massachusetts 02129</wicri:regionArea>
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<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
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<affiliation></affiliation>
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<author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA</wicri:regionArea>
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<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
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<wicri:regionArea>Department of Critical Care Medicine, The Queen’s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Drive, Edinburgh EH16 4TJ</wicri:regionArea>
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<wicri:regionArea>Department of Critical Care Medicine, The Queen’s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Drive, Edinburgh EH16 4TJ</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
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<wicri:regionArea>Department of Critical Care Medicine, The Queen’s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Drive, Edinburgh EH16 4TJ</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
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<wicri:regionArea>Department of Critical Care Medicine, The Queen’s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Drive, Edinburgh EH16 4TJ</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
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<wicri:regionArea>Department of Critical Care Medicine, The Queen’s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Drive, Edinburgh EH16 4TJ</wicri:regionArea>
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<wicri:regionArea>Generation Scotland, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
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<author><name sortKey="Taylor, J" sort="Taylor, J" uniqKey="Taylor J" first="J." last="Taylor">J. Taylor</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN</wicri:regionArea>
<wicri:noRegion>Aberdeen AB25 2ZN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Webster Local Lead Investigator, N" sort="Webster Local Lead Investigator, N" uniqKey="Webster Local Lead Investigator N" first="N." last="Webster Local Lead Investigator">N. Webster Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN</wicri:regionArea>
<wicri:noRegion>Aberdeen AB25 2ZN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor Local Lead Investigator, I" sort="Taylor Local Lead Investigator, I" uniqKey="Taylor Local Lead Investigator I" first="I." last="Taylor Local Lead Investigator">I. Taylor Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Ayr Hospital, Dallmellington Road, Ayr KA6 6DX</wicri:regionArea>
<wicri:noRegion>Ayr KA6 6DX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aldridge Local Lead Investigator, J" sort="Aldridge Local Lead Investigator, J" uniqKey="Aldridge Local Lead Investigator J" first="J." last="Aldridge Local Lead Investigator">J. Aldridge Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Borders General Hospital, Melrose TD6 9BS</wicri:regionArea>
<wicri:noRegion>Melrose TD6 9BS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dornan, R" sort="Dornan, R" uniqKey="Dornan R" first="R." last="Dornan">R. Dornan</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Borders General Hospital, Melrose TD6 9BS</wicri:regionArea>
<wicri:noRegion>Melrose TD6 9BS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richard, C" sort="Richard, C" uniqKey="Richard C" first="C." last="Richard">C. Richard</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Borders General Hospital, Melrose TD6 9BS</wicri:regionArea>
<wicri:noRegion>Melrose TD6 9BS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gilmour, D" sort="Gilmour, D" uniqKey="Gilmour D" first="D." last="Gilmour">D. Gilmour</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Crosshouse Hospital, Kilmarnock KA2 0BE</wicri:regionArea>
<wicri:noRegion>Kilmarnock KA2 0BE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Simmons Local Lead Investigator, R" sort="Simmons Local Lead Investigator, R" uniqKey="Simmons Local Lead Investigator R" first="R." last="Simmons Local Lead Investigator">R. Simmons Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Crosshouse Hospital, Kilmarnock KA2 0BE</wicri:regionArea>
<wicri:noRegion>Kilmarnock KA2 0BE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="White Local Lead Investigator, R" sort="White Local Lead Investigator, R" uniqKey="White Local Lead Investigator R" first="R." last="White Local Lead Investigator">R. White Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Crosshouse Hospital, Kilmarnock KA2 0BE</wicri:regionArea>
<wicri:noRegion>Kilmarnock KA2 0BE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jardine, C" sort="Jardine, C" uniqKey="Jardine C" first="C." last="Jardine">C. Jardine</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP</wicri:regionArea>
<wicri:noRegion>Dumfries DG1 4AP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams Local Lead Investigator, D" sort="Williams Local Lead Investigator, D" uniqKey="Williams Local Lead Investigator D" first="D." last="Williams Local Lead Investigator">D. Williams Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP</wicri:regionArea>
<wicri:noRegion>Dumfries DG1 4AP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Booth Local Lead Investigator, M" sort="Booth Local Lead Investigator, M" uniqKey="Booth Local Lead Investigator M" first="M." last="Booth Local Lead Investigator">M. Booth Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Glasgow Royal Infirmary, Glasgow G4 0SF</wicri:regionArea>
<wicri:noRegion>Glasgow G4 0SF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quasim, T" sort="Quasim, T" uniqKey="Quasim T" first="T." last="Quasim">T. Quasim</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Glasgow Royal Infirmary, Glasgow G4 0SF</wicri:regionArea>
<wicri:noRegion>Glasgow G4 0SF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watson, V" sort="Watson, V" uniqKey="Watson V" first="V." last="Watson">V. Watson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Hairmyres Hospital, Lanarkshire G75 8RG</wicri:regionArea>
<wicri:noRegion>Lanarkshire G75 8RG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henry, P" sort="Henry, P" uniqKey="Henry P" first="P." last="Henry">P. Henry</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Inverclyde Royal Hospital, Greenock PA16 0XN</wicri:regionArea>
<wicri:noRegion>Greenock PA16 0XN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Munro, F" sort="Munro, F" uniqKey="Munro F" first="F." last="Munro">F. Munro</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Inverclyde Royal Hospital, Greenock PA16 0XN</wicri:regionArea>
<wicri:noRegion>Greenock PA16 0XN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bell, L" sort="Bell, L" uniqKey="Bell L" first="L." last="Bell">L. Bell</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Monklands Hospital, Airdrie ML6 0JS</wicri:regionArea>
<wicri:noRegion>Airdrie ML6 0JS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruddy Local Lead Investigator, J" sort="Ruddy Local Lead Investigator, J" uniqKey="Ruddy Local Lead Investigator J" first="J." last="Ruddy Local Lead Investigator">J. Ruddy Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Monklands Hospital, Airdrie ML6 0JS</wicri:regionArea>
<wicri:noRegion>Airdrie ML6 0JS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cole Local Lead Investigator, S" sort="Cole Local Lead Investigator, S" uniqKey="Cole Local Lead Investigator S" first="S." last="Cole Local Lead Investigator">S. Cole Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Ninewells Hospital, Dundee DD1 9SY</wicri:regionArea>
<wicri:noRegion>Dundee DD1 9SY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southward, J" sort="Southward, J" uniqKey="Southward J" first="J." last="Southward">J. Southward</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Ninewells Hospital, Dundee DD1 9SY</wicri:regionArea>
<wicri:noRegion>Dundee DD1 9SY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Allcoat, P" sort="Allcoat, P" uniqKey="Allcoat P" first="P." last="Allcoat">P. Allcoat</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Queen Margaret Hospital, Dunfermline KY12 0SU</wicri:regionArea>
<wicri:noRegion>Dunfermline KY12 0SU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gray, S" sort="Gray, S" uniqKey="Gray S" first="S." last="Gray">S. Gray</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Queen Margaret Hospital, Dunfermline KY12 0SU</wicri:regionArea>
<wicri:noRegion>Dunfermline KY12 0SU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcdougall Local Lead Investigator, M" sort="Mcdougall Local Lead Investigator, M" uniqKey="Mcdougall Local Lead Investigator M" first="M." last="Mcdougall Local Lead Investigator">M. Mcdougall Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Queen Margaret Hospital, Dunfermline KY12 0SU</wicri:regionArea>
<wicri:noRegion>Dunfermline KY12 0SU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matheson, J" sort="Matheson, J" uniqKey="Matheson J" first="J." last="Matheson">J. Matheson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Raigmore Hospital, Inverness IV2 3UJ</wicri:regionArea>
<wicri:noRegion>Inverness IV2 3UJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whiteside Local Lead Investigator, J" sort="Whiteside Local Lead Investigator, J" uniqKey="Whiteside Local Lead Investigator J" first="J." last="Whiteside Local Lead Investigator">J. Whiteside Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Raigmore Hospital, Inverness IV2 3UJ</wicri:regionArea>
<wicri:noRegion>Inverness IV2 3UJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alcorn, D" sort="Alcorn, D" uniqKey="Alcorn D" first="D." last="Alcorn">D. Alcorn</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Royal Alexandra Hospital, Paisley PA2 9PN</wicri:regionArea>
<wicri:noRegion>Paisley PA2 9PN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rooney Local Lead Investigator, K" sort="Rooney Local Lead Investigator, K" uniqKey="Rooney Local Lead Investigator K" first="K." last="Rooney Local Lead Investigator">K. Rooney Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Royal Alexandra Hospital, Paisley PA2 9PN</wicri:regionArea>
<wicri:noRegion>Paisley PA2 9PN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sundaram, R" sort="Sundaram, R" uniqKey="Sundaram R" first="R." last="Sundaram">R. Sundaram</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Royal Alexandra Hospital, Paisley PA2 9PN</wicri:regionArea>
<wicri:noRegion>Paisley PA2 9PN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Imrie Local Lead Investigator, G" sort="Imrie Local Lead Investigator, G" uniqKey="Imrie Local Lead Investigator G" first="G." last="Imrie Local Lead Investigator">G. Imrie Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Southern General Hospital, Glasgow G51 4TF</wicri:regionArea>
<wicri:noRegion>Glasgow G51 4TF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bruce, J" sort="Bruce, J" uniqKey="Bruce J" first="J." last="Bruce">J. Bruce</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, St John’s Hospital, Livingston EH54 6PP</wicri:regionArea>
<wicri:noRegion>Livingston EH54 6PP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcguigan, K" sort="Mcguigan, K" uniqKey="Mcguigan K" first="K." last="Mcguigan">K. Mcguigan</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, St John’s Hospital, Livingston EH54 6PP</wicri:regionArea>
<wicri:noRegion>Livingston EH54 6PP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moultrie Local Lead Investigator, S" sort="Moultrie Local Lead Investigator, S" uniqKey="Moultrie Local Lead Investigator S" first="S." last="Moultrie Local Lead Investigator">S. Moultrie Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, St John’s Hospital, Livingston EH54 6PP</wicri:regionArea>
<wicri:noRegion>Livingston EH54 6PP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cairns Local Lead Investigator, C" sort="Cairns Local Lead Investigator, C" uniqKey="Cairns Local Lead Investigator C" first="C." last="Cairns Local Lead Investigator">C. Cairns Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Stirling Royal Infirmary, Stirling FK8 2AU</wicri:regionArea>
<wicri:noRegion>Stirling FK8 2AU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grant, J" sort="Grant, J" uniqKey="Grant J" first="J." last="Grant">J. Grant</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Stirling Royal Infirmary, Stirling FK8 2AU</wicri:regionArea>
<wicri:noRegion>Stirling FK8 2AU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hughes, M" sort="Hughes, M" uniqKey="Hughes M" first="M." last="Hughes">M. Hughes</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Stirling Royal Infirmary, Stirling FK8 2AU</wicri:regionArea>
<wicri:noRegion>Stirling FK8 2AU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murdoch Local Lead Investigator, C" sort="Murdoch Local Lead Investigator, C" uniqKey="Murdoch Local Lead Investigator C" first="C." last="Murdoch Local Lead Investigator">C. Murdoch Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Stobhill Hospital, Glasgow G21 3UW</wicri:regionArea>
<wicri:noRegion>Glasgow G21 3UW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davidson Local Lead Investigator, A" sort="Davidson Local Lead Investigator, A" uniqKey="Davidson Local Lead Investigator A" first="A." last="Davidson Local Lead Investigator">A. Davidson Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Victoria Hospital, Glasgow G42 9TY</wicri:regionArea>
<wicri:noRegion>Glasgow G42 9TY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harris, G" sort="Harris, G" uniqKey="Harris G" first="G." last="Harris">G. Harris</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paterson, R" sort="Paterson, R" uniqKey="Paterson R" first="R." last="Paterson">R. Paterson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallis Local Lead Investigator, C" sort="Wallis Local Lead Investigator, C" uniqKey="Wallis Local Lead Investigator C" first="C." last="Wallis Local Lead Investigator">C. Wallis Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Binning Local Lead Investigator, S" sort="Binning Local Lead Investigator, S" uniqKey="Binning Local Lead Investigator S" first="S." last="Binning Local Lead Investigator">S. Binning Local Lead Investigator</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Western Infirmary, Glasgow G11 6NT</wicri:regionArea>
<wicri:noRegion>Glasgow G11 6NT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollock, M" sort="Pollock, M" uniqKey="Pollock M" first="M." last="Pollock">M. Pollock</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Intensive Care Unit, Western Infirmary, Glasgow G11 6NT</wicri:regionArea>
<wicri:noRegion>Glasgow G11 6NT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Antonelli, J" sort="Antonelli, J" uniqKey="Antonelli J" first="J." last="Antonelli">J. Antonelli</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Clinical Research Facility, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duncan, A" sort="Duncan, A" uniqKey="Duncan A" first="A." last="Duncan">A. Duncan</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Clinical Research Facility, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gibson, J" sort="Gibson, J" uniqKey="Gibson J" first="J." last="Gibson">J. Gibson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Clinical Research Facility, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcculloch, C" sort="Mcculloch, C" uniqKey="Mcculloch C" first="C." last="Mcculloch">C. Mcculloch</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Clinical Research Facility, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murphy, L" sort="Murphy, L" uniqKey="Murphy L" first="L." last="Murphy">L. Murphy</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Clinical Research Facility, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU</wicri:regionArea>
<wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haley, C" sort="Haley, C" uniqKey="Haley C" first="C." last="Haley">C. Haley</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Faulkner, G" sort="Faulkner, G" uniqKey="Faulkner G" first="G." last="Faulkner">G. Faulkner</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, T" sort="Freeman, T" uniqKey="Freeman T" first="T." last="Freeman">T. Freeman</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hume, D A" sort="Hume, D A" uniqKey="Hume D" first="D. A." last="Hume">D. A. Hume</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baillie Principal Investigator, J K" sort="Baillie Principal Investigator, J K" uniqKey="Baillie Principal Investigator J" first="J. K." last="Baillie Principal Investigator">J. K. Baillie Principal Investigator</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chaussabel, D" sort="Chaussabel, D" uniqKey="Chaussabel D" first="D." last="Chaussabel">D. Chaussabel</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Benaroya Research Institute, 1201 9th Avenue, Seattle, Washington 98101-2795</wicri:regionArea>
<wicri:noRegion>Washington 98101-2795</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adamson, W E" sort="Adamson, W E" uniqKey="Adamson W" first="W. E." last="Adamson">W. E. Adamson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>West of Scotland Specialist Virology Centre, Gartnavel General Hospital, Glasgow and Clyde Health Board, 1053 Great Western Road, Glasgow G12 0YN</wicri:regionArea>
<wicri:noRegion>Glasgow G12 0YN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carman, W F" sort="Carman, W F" uniqKey="Carman W" first="W. F." last="Carman">W. F. Carman</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>West of Scotland Specialist Virology Centre, Gartnavel General Hospital, Glasgow and Clyde Health Board, 1053 Great Western Road, Glasgow G12 0YN</wicri:regionArea>
<wicri:noRegion>Glasgow G12 0YN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, C" sort="Thompson, C" uniqKey="Thompson C" first="C." last="Thompson">C. Thompson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Health Protection Agency, Microbiology Services Colindale, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zambon, M C" sort="Zambon, M C" uniqKey="Zambon M" first="M. C." last="Zambon">M. C. Zambon</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Health Protection Agency, Microbiology Services Colindale, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aylin, P" sort="Aylin, P" uniqKey="Aylin P" first="P." last="Aylin">P. Aylin</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ashby, D" sort="Ashby, D" uniqKey="Ashby D" first="D." last="Ashby">D. Ashby</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barclay, W S" sort="Barclay, W S" uniqKey="Barclay W" first="W. S." last="Barclay">W. S. Barclay</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brett, S J" sort="Brett, S J" uniqKey="Brett S" first="S. J." last="Brett">S. J. Brett</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cookson, W O" sort="Cookson, W O" uniqKey="Cookson W" first="W. O." last="Cookson">W. O. Cookson</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drumright, L N" sort="Drumright, L N" uniqKey="Drumright L" first="L. N." last="Drumright">L. N. Drumright</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dunning, J" sort="Dunning, J" uniqKey="Dunning J" first="J." last="Dunning">J. Dunning</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elderfield, R A" sort="Elderfield, R A" uniqKey="Elderfield R" first="R. A." last="Elderfield">R. A. Elderfield</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Alvarez, L" sort="Garcia Alvarez, L" uniqKey="Garcia Alvarez L" first="L." last="Garcia-Alvarez">L. Garcia-Alvarez</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gazzard, B G" sort="Gazzard, B G" uniqKey="Gazzard B" first="B. G." last="Gazzard">B. G. Gazzard</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Griffiths, M J" sort="Griffiths, M J" uniqKey="Griffiths M" first="M. J." last="Griffiths">M. J. Griffiths</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Habibi, M S" sort="Habibi, M S" uniqKey="Habibi M" first="M. S." last="Habibi">M. S. Habibi</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hansel, T T" sort="Hansel, T T" uniqKey="Hansel T" first="T. T." last="Hansel">T. T. Hansel</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Herberg, J A" sort="Herberg, J A" uniqKey="Herberg J" first="J. A." last="Herberg">J. A. Herberg</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holmes, A H" sort="Holmes, A H" uniqKey="Holmes A" first="A. H." last="Holmes">A. H. Holmes</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hussell, T" sort="Hussell, T" uniqKey="Hussell T" first="T." last="Hussell">T. Hussell</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Johnston, S L" sort="Johnston, S L" uniqKey="Johnston S" first="S. L." last="Johnston">S. L. Johnston</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kon, O M" sort="Kon, O M" uniqKey="Kon O" first="O. M." last="Kon">O. M. Kon</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Levin, M" sort="Levin, M" uniqKey="Levin M" first="M." last="Levin">M. Levin</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moffatt, M F" sort="Moffatt, M F" uniqKey="Moffatt M" first="M. F." last="Moffatt">M. F. Moffatt</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nadel, S" sort="Nadel, S" uniqKey="Nadel S" first="S." last="Nadel">S. Nadel</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Openshaw, P J" sort="Openshaw, P J" uniqKey="Openshaw P" first="P. J." last="Openshaw">P. J. Openshaw</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Warner, J O" sort="Warner, J O" uniqKey="Warner J" first="J. O." last="Warner">J. O. Warner</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG</wicri:regionArea>
<wicri:noRegion>London W2 1PG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aston, S J" sort="Aston, S J" uniqKey="Aston S" first="S. J." last="Aston">S. J. Aston</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA</wicri:regionArea>
<wicri:noRegion>Liverpool L3 5QA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gordon, S B" sort="Gordon, S B" uniqKey="Gordon S" first="S. B." last="Gordon">S. B. Gordon</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA</wicri:regionArea>
<wicri:noRegion>Liverpool L3 5QA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hay, A" sort="Hay, A" uniqKey="Hay A" first="A." last="Hay">A. Hay</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>National Institute for Medical Research (NIMR), The Ridgeway, London NW7 1AA</wicri:regionArea>
<wicri:noRegion>London NW7 1AA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccauley, J" sort="Mccauley, J" uniqKey="Mccauley J" first="J." last="Mccauley">J. Mccauley</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>National Institute for Medical Research (NIMR), The Ridgeway, London NW7 1AA</wicri:regionArea>
<wicri:noRegion>London NW7 1AA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Arra, A" sort="O Arra, A" uniqKey="O Arra A" first="A." last="O Arra">A. O Arra</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>National Institute for Medical Research (NIMR), The Ridgeway, London NW7 1AA</wicri:regionArea>
<wicri:noRegion>London NW7 1AA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Banchereau, J" sort="Banchereau, J" uniqKey="Banchereau J" first="J." last="Banchereau">J. Banchereau</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Roche, 340 Kingsland Street, Nutley, New Jersey 07110-1199</wicri:regionArea>
<wicri:noRegion>New Jersey 07110-1199</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayward, A" sort="Hayward, A" uniqKey="Hayward A" first="A." last="Hayward">A. Hayward</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>University College London, Gower Street, London, WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kellam, P" sort="Kellam, P" uniqKey="Kellam P" first="P." last="Kellam">P. Kellam</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>University College London, Gower Street, London, WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baillie, J K" sort="Baillie, J K" uniqKey="Baillie J" first="J. K." last="Baillie">J. K. Baillie</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hume, D A" sort="Hume, D A" uniqKey="Hume D" first="D. A." last="Hume">D. A. Hume</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simmonds, P" sort="Simmonds, P" uniqKey="Simmonds P" first="P." last="Simmonds">P. Simmonds</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcnamara, P S" sort="Mcnamara, P S" uniqKey="Mcnamara P" first="P. S." last="Mcnamara">P. S. Mcnamara</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP</wicri:regionArea>
<wicri:noRegion>Liverpool L12 2AP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Semple, M G" sort="Semple, M G" uniqKey="Semple M" first="M. G." last="Semple">M. G. Semple</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP</wicri:regionArea>
<wicri:noRegion>Liverpool L12 2AP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smyth, R L" sort="Smyth, R L" uniqKey="Smyth R" first="R. L." last="Smyth">R. L. Smyth</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP</wicri:regionArea>
<wicri:noRegion>Liverpool L12 2AP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nguyen Van Tam, J S" sort="Nguyen Van Tam, J S" uniqKey="Nguyen Van Tam J" first="J. S." last="Nguyen-Van-Tam">J. S. Nguyen-Van-Tam</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB</wicri:regionArea>
<orgName type="university">Université de Nottingham</orgName>
<placeName><settlement type="city">Nottingham</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Nottinghamshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ho, L P" sort="Ho, L P" uniqKey="Ho L" first="L.-P." last="Ho">L.-P. Ho</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmichael, A J" sort="Mcmichael, A J" uniqKey="Mcmichael A" first="A. J." last="Mcmichael">A. J. Mcmichael</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kellam, P" sort="Kellam, P" uniqKey="Kellam P" first="P." last="Kellam">P. Kellam</name>
<affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Nature</title>
<idno type="ISSN">0028-0836</idno>
<idno type="eISSN">1476-4687</idno>
<imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher>
<date when="2012-04-26">2012-04-26</date>
<biblScope unit="vol">484</biblScope>
<biblScope unit="issue">7395</biblScope>
<biblScope unit="page" from="519">519</biblScope>
<biblScope unit="page" to="523">523</biblScope>
<date type="Copyright" when="2012">2012</date>
</imprint>
<idno type="ISSN">0028-0836</idno>
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<front><div type="abstract" xml:lang="eng">Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Grand Londres</li>
<li>Nottinghamshire</li>
<li>Oxfordshire</li>
<li>Écosse</li>
</region>
<settlement><li>Cambridge</li>
<li>Londres</li>
<li>Nottingham</li>
<li>Oxford</li>
<li>Édimbourg</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université d'Oxford</li>
<li>Université d'Édimbourg</li>
<li>Université de Cambridge</li>
<li>Université de Nottingham</li>
</orgName>
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<name sortKey="Dornan, R" sort="Dornan, R" uniqKey="Dornan R" first="R." last="Dornan">R. Dornan</name>
<name sortKey="Dougan, Gordon" sort="Dougan, Gordon" uniqKey="Dougan G" first="Gordon" last="Dougan">Gordon Dougan</name>
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<name sortKey="Duncan, A" sort="Duncan, A" uniqKey="Duncan A" first="A." last="Duncan">A. Duncan</name>
<name sortKey="Dunning, J" sort="Dunning, J" uniqKey="Dunning J" first="J." last="Dunning">J. Dunning</name>
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<name sortKey="Henry, P" sort="Henry, P" uniqKey="Henry P" first="P." last="Henry">P. Henry</name>
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<name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name>
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<name sortKey="Kon, O M" sort="Kon, O M" uniqKey="Kon O" first="O. M." last="Kon">O. M. Kon</name>
<name sortKey="Levin, M" sort="Levin, M" uniqKey="Levin M" first="M." last="Levin">M. Levin</name>
<name sortKey="Matheson, J" sort="Matheson, J" uniqKey="Matheson J" first="J." last="Matheson">J. Matheson</name>
<name sortKey="Mccauley, J" sort="Mccauley, J" uniqKey="Mccauley J" first="J." last="Mccauley">J. Mccauley</name>
<name sortKey="Mcculloch, C" sort="Mcculloch, C" uniqKey="Mcculloch C" first="C." last="Mcculloch">C. Mcculloch</name>
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<name sortKey="Nadel, S" sort="Nadel, S" uniqKey="Nadel S" first="S." last="Nadel">S. Nadel</name>
<name sortKey="Nguyen Van Tam, J S" sort="Nguyen Van Tam, J S" uniqKey="Nguyen Van Tam J" first="J. S." last="Nguyen-Van-Tam">J. S. Nguyen-Van-Tam</name>
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<name sortKey="O Arra, A" sort="O Arra, A" uniqKey="O Arra A" first="A." last="O Arra">A. O Arra</name>
<name sortKey="Openshaw, P J" sort="Openshaw, P J" uniqKey="Openshaw P" first="P. J." last="Openshaw">P. J. Openshaw</name>
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<name sortKey="Southward, J" sort="Southward, J" uniqKey="Southward J" first="J." last="Southward">J. Southward</name>
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<name sortKey="Taylor, J" sort="Taylor, J" uniqKey="Taylor J" first="J." last="Taylor">J. Taylor</name>
<name sortKey="Thompson, C" sort="Thompson, C" uniqKey="Thompson C" first="C." last="Thompson">C. Thompson</name>
<name sortKey="Tyler Smith, Chris" sort="Tyler Smith, Chris" uniqKey="Tyler Smith C" first="Chris" last="Tyler-Smith">Chris Tyler-Smith</name>
<name sortKey="Wallis Local Lead Investigator, C" sort="Wallis Local Lead Investigator, C" uniqKey="Wallis Local Lead Investigator C" first="C." last="Wallis Local Lead Investigator">C. Wallis Local Lead Investigator</name>
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<name sortKey="Walsh, Tim S" sort="Walsh, Tim S" uniqKey="Walsh T" first="Tim S." last="Walsh">Tim S. Walsh</name>
<name sortKey="Warner, J O" sort="Warner, J O" uniqKey="Warner J" first="J. O." last="Warner">J. O. Warner</name>
<name sortKey="Wash, Rachael S" sort="Wash, Rachael S" uniqKey="Wash R" first="Rachael S." last="Wash">Rachael S. Wash</name>
<name sortKey="Watson, V" sort="Watson, V" uniqKey="Watson V" first="V." last="Watson">V. Watson</name>
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<name sortKey="Whiteside Local Lead Investigator, J" sort="Whiteside Local Lead Investigator, J" uniqKey="Whiteside Local Lead Investigator J" first="J." last="Whiteside Local Lead Investigator">J. Whiteside Local Lead Investigator</name>
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<name sortKey="Xue, Yali" sort="Xue, Yali" uniqKey="Xue Y" first="Yali" last="Xue">Yali Xue</name>
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<country name="États-Unis"><noRegion><name sortKey="Pertel, Thomas" sort="Pertel, Thomas" uniqKey="Pertel T" first="Thomas" last="Pertel">Thomas Pertel</name>
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<name sortKey="Banchereau, J" sort="Banchereau, J" uniqKey="Banchereau J" first="J." last="Banchereau">J. Banchereau</name>
<name sortKey="Brass, Abraham L" sort="Brass, Abraham L" uniqKey="Brass A" first="Abraham L." last="Brass">Abraham L. Brass</name>
<name sortKey="Brass, Abraham L" sort="Brass, Abraham L" uniqKey="Brass A" first="Abraham L." last="Brass">Abraham L. Brass</name>
<name sortKey="Chaussabel, D" sort="Chaussabel, D" uniqKey="Chaussabel D" first="D." last="Chaussabel">D. Chaussabel</name>
<name sortKey="Chin, Christopher R" sort="Chin, Christopher R" uniqKey="Chin C" first="Christopher R." last="Chin">Christopher R. Chin</name>
<name sortKey="Feeley, Eric M" sort="Feeley, Eric M" uniqKey="Feeley E" first="Eric M." last="Feeley">Eric M. Feeley</name>
<name sortKey="John, Sinu P" sort="John, Sinu P" uniqKey="John S" first="Sinu P." last="John">Sinu P. John</name>
<name sortKey="Sims, Jennifer S" sort="Sims, Jennifer S" uniqKey="Sims J" first="Jennifer S." last="Sims">Jennifer S. Sims</name>
</country>
<country name="Italie"><noRegion><name sortKey="Colonna, Vincenza" sort="Colonna, Vincenza" uniqKey="Colonna V" first="Vincenza" last="Colonna">Vincenza Colonna</name>
</noRegion>
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IFITM3 restricts the morbidity and mortality associated with influenza

IFITM3 restricts the morbidity and mortality associated with influenza

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